A nurse is preparing a client for a computed tomography scan of the chest with intravenous contrast. The client reports taking metformin for type 2 diabetes. Which action should the nurse take before the procedure?
Correct! Metformin must be held before procedures using iodinated intravenous contrast because contrast agents can cause acute kidney injury. If renal function is impaired, metformin accumulates (since it is renally cleared) and can cause lactic acidosis — a rare but potentially fatal complication. The standard protocol is to hold metformin on the day of the procedure and for 48 hours after, then assess renal function before restarting.
Clinical pearl: Clinical Pearl: Metformin and contrast protocol: hold metformin on the day of the contrast procedure. After the procedure, recheck renal function (creatinine, eGFR) at 48 hours. If renal function is stable and adequate, metformin can be restarted. This applies to all forms of iodinated contrast — intravenous, intra-arterial, and intrathecal. Alert the radiology team and provider about metformin use during any pre-procedure assessment.